Node erk {
  logic = (mek);
  rate_up = @logic ? $u_erk : 0;
  rate_down = @logic ? 0 : $d_erk;
}

Node ikk {
  logic = (nik);
  rate_up = @logic ? $u_ikk : 0;
  rate_down = @logic ? 0 : $d_ikk;
}

Node gsk3 {
  logic = (!akt);
  rate_up = @logic ? $u_gsk3 : 0;
  rate_down = @logic ? 0 : $d_gsk3;
}

Node nfkb {
  logic = (!ikb);
  rate_up = @logic ? $u_nfkb : 0;
  rate_down = @logic ? 0 : $d_nfkb;
}

Node ask1 {
  logic = (traf2);
  rate_up = @logic ? $u_ask1 : 0;
  rate_down = @logic ? 0 : $d_ask1;
}

Node ras {
  logic = (sos);
  rate_up = @logic ? $u_ras : 0;
  rate_down = @logic ? 0 : $d_ras;
}

Node egf {
  logic = (egf);
  rate_up = @logic ? $u_egf : 0;
  rate_down = @logic ? 0 : $d_egf;
}

Node egfr {
  logic = (egf);
  rate_up = @logic ? $u_egfr : 0;
  rate_down = @logic ? 0 : $d_egfr;
}

Node traf2 {
  logic = (tnfr);
  rate_up = @logic ? $u_traf2 : 0;
  rate_down = @logic ? 0 : $d_traf2;
}

Node ikb {
  logic = (!ikk) | (ikk & ex);
  rate_up = @logic ? $u_ikb : 0;
  rate_down = @logic ? 0 : $d_ikb;
}

Node map3k1 {
  logic = (ras);
  rate_up = @logic ? $u_map3k1 : 0;
  rate_down = @logic ? 0 : $d_map3k1;
}

Node tnfr {
  logic = (tnfa);
  rate_up = @logic ? $u_tnfr : 0;
  rate_down = @logic ? 0 : $d_tnfr;
}

Node ap1 {
  logic = (cjun);
  rate_up = @logic ? $u_ap1 : 0;
  rate_down = @logic ? 0 : $d_ap1;
}

Node mek {
  logic = (raf1);
  rate_up = @logic ? $u_mek : 0;
  rate_down = @logic ? 0 : $d_mek;
}

Node mkk4 {
  logic = (map3k1 & map3k7);
  rate_up = @logic ? $u_mkk4 : 0;
  rate_down = @logic ? 0 : $d_mkk4;
}

Node ex {
  logic = (nfkb);
  rate_up = @logic ? $u_ex : 0;
  rate_down = @logic ? 0 : $d_ex;
}

Node tnfa {
  logic = (tnfa);
  rate_up = @logic ? $u_tnfa : 0;
  rate_down = @logic ? 0 : $d_tnfa;
}

Node raf1 {
  logic = (ras);
  rate_up = @logic ? $u_raf1 : 0;
  rate_down = @logic ? 0 : $d_raf1;
}

Node map3k7 {
  logic = (traf2);
  rate_up = @logic ? $u_map3k7 : 0;
  rate_down = @logic ? 0 : $d_map3k7;
}

Node mkk7 {
  logic = (!ask1 & map3k1) | (ask1);
  rate_up = @logic ? $u_mkk7 : 0;
  rate_down = @logic ? 0 : $d_mkk7;
}

Node cjun {
  logic = (jnk);
  rate_up = @logic ? $u_cjun : 0;
  rate_down = @logic ? 0 : $d_cjun;
}

Node sos {
  logic = (egfr & !ph);
  rate_up = @logic ? $u_sos : 0;
  rate_down = @logic ? 0 : $d_sos;
}

Node jnk {
  logic = (mkk7);
  rate_up = @logic ? $u_jnk : 0;
  rate_down = @logic ? 0 : $d_jnk;
}

Node pi3k {
  logic = (egfr);
  rate_up = @logic ? $u_pi3k : 0;
  rate_down = @logic ? 0 : $d_pi3k;
}

Node p38 {
  logic = (mkk4);
  rate_up = @logic ? $u_p38 : 0;
  rate_down = @logic ? 0 : $d_p38;
}

Node akt {
  logic = (pi3k);
  rate_up = @logic ? $u_akt : 0;
  rate_down = @logic ? 0 : $d_akt;
}

Node ph {
  logic = (!erk & ph) | (erk);
  rate_up = @logic ? $u_ph : 0;
  rate_down = @logic ? 0 : $d_ph;
}

Node nik {
  logic = (map3k7);
  rate_up = @logic ? $u_nik : 0;
  rate_down = @logic ? 0 : $d_nik;
}